Experimental Evaluation of some central nervous system activities of Calcium Channel Blockers: Effect on isolation Combativeness and Suppression of Conditioned Avoidance Response

Calcium channel blockers are widely used in the treatment of cardiovascular disorders for their actions on the voltage sensitive calcium channels in cardiac and smooth muscles. The reorganization on calcium channel antagonist binding sites in the limbic regions of the brain, raises the hope that these might also be helpful in some behavioural disorders. Calcium channel blockers act by blocking one more type of calcium channel located in the cells. An interesting finding noted is that blocking of voltage gated channels results in antinoceception. Voltage gated T, N, L type of calcium channel blockers contribute significantly to excitability of sensory neurons but the N channels are particularly important because they control release of neurotransmitters from the peripheral and central terminals. Recent studies provided a link between opioids system and calcium channels.